Prolotherapy is an injection technique where an irritant solution (usually dextrose i.e. a type of sugar) is injected to the area of pain or tissue weakness under landmark or ultrasound guidance. The goal is the stimulation of beneficial inflammation to promote the production of new connective tissue. It is an option for some forms of joint instability, ligament pain, and some other settings.

The evidence for prolotherapy is mixed.

Prolotherapy is not funded by ACC and generally not funded by other insurance companies.