HAEMOPHILIA A (FACTOR VIII) REPLACEMENT PRODUCTS

For people with Haemophilia A there are three different factor replacement products available:

1. CSL (Biostate) FVIII: a plasma derived product ordered through Blood Bank.
2. Advate (Takeda):  a recombinant short acting factor VIII replacement product.
3. Adynovate (Takeda): a recombinant, long acting factor VIII replacement product.
4. Hemlibra (Roche) : monoclonal antibody , long acting . Pharmacy (only drug) can fill scripts.    

Advate and Adynovate are kept in the Haemophilia Centre fridge, Building 8, Level 5, Auckland City Hospital and there's also a afterhour supply in Bloodbank. For a supply of Advate or Adynovate, Monday-Friday 0730-1600 hours please contact the Auckland Haemophilia Centre ext: 25285/0211954262 . Afterhours please contact bloodbank. 

HAEMOPHILIA B (FACTOR IX) REPLACEMENT PRODUCTS

For people with Haemophilia B there are two different factor replacement products available:

1. Rixubis (Takeda): a recombinant, short-acting factor IX replacement product.
2. Alprolix (CSL):  a recombinant, long-acting factor IX replacement product

Alprolix and Rixubis are kept in the Haemophilia Centre fridge, Building 8, Auckland City Hospital or afterhour Bloodbank .

It is important to check which factor product each person uses, for several reasons:

• If someone has developed an Inhibitor and has received therapy for this, i.e. has been 'Immune Tolerised' on a certain product, we don’t know if changing the product will have an effect on the Inhibitor.
• People may respond differently to different products. For example, a patient may get different Factor rise in their blood to a recombinant product and a plasma derived product. 

INHIBITORS

When a person develops an inhibitor, the usual replacement products are ineffective, and to stop bleeding episodes, FVIIa (NovoSeven) or FEIBA is used. Novoseven is kept on the Haemophilia Centre clinic bench and FEIBA is stored in the refrigerator or afterhours from the bloodbank.

If you would like more information on the types of clotting factors used by the Auckland Haemophilia Centre, please call the Centre for advice on (09) 307 4949 x25285/0211954262.